As the state records an 80% vaccination rate, the state government announced there will be no limits on travel with regional tourism set to spike.

EGHS chief executive Peter Armstrong said he is "confident" the easing of restrictions will run smoothly.

"People just need to be smart like they have been for the past 18 months and we should be fine," he said.

"The business community and tourism in the Grampians has been looking forward to this for a long time, there is going to be a big boost for the local community."

"We have had a couple years to prepare for this, we are a lot better prepared than we were 12 months ago, we are confident."

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Mr Armstrong said the latest COVID-19 outbreak prepared EGHS for this weekend.

"Our staff are keen and are well equipped, the recent outbreak was like a trial run.

"They are looking forward to as much as anyone else to have a bit more freedom.

EGHS infection control coordinator Leeanne Atkinson said the community "shouldn't have any anxiety" about the sudden influx of tourism.

"Our vaccination rates are high enough now that we don't have a great deal of anxiety," she said.

"This was always the plan.

"Once vaccinations hit a certain point, we would reduce the levels of restrictions and people would be able to mingle."

Mrs Atkinson encouraged residents to still follow the health guidelines, despite the easing of restrictions.

"It comes back to all of those basic things," she said.

"It comes back to cough etiquette, social distancing, QR coding in, hand hygiene.

"If you have symptoms get tested, don't think it is just a cold, absolutely get tested.

"Everyone needs to follow the public health guidelines regarding how many people can come to your home.

"Be aware when you go to eat out or do something that has a public order in place regarding vaccinations that if you are not double vaxxed don't try to enter."

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Visitors to the Grampians region means a boost for business which is good news to the ears of Grampians Tourism chief executive Marc Sleeman.

He said the state government's announcement on Sunday caught some business off-guard, but he is confident the Grampians can handle the new faces.

"The forward bookings for our region are extremely strong right through to Christmas and so the early signs are very positive for the destination," he said.

"It provided a sense of chaos for a lot of our operators and there was a lot of unknowns.

"Because of the changes to a lot of the rules and regulations it has been quite frustrating for some of our operators so we are trying to share the relevant information as it comes to hand.

"The feedback we are getting is that some of our partners weren't prepared for the opening days moving forward and it has got some of the business off-guard a bit.

"The reality is that there is going to be some business that won't be able to open up and it will be difficult to provide a visitors experience without our full team of businesses open.

"The first couple of weeks are going to be challenging for everyone, but we have got pretty good at being flexible."

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Mr Sleeman also said he was confident that the region would continue to record strong visitor numbers as restrictions ease.

"When you compare the first half the year of 2019 to the first half of the year in 2021, the Grampians region had a 40 per cent increase in visitor expenditure and a 11 per cent increase in visitor nights in region," he said.

"We led the state on both of those metrics.

"History shows us that once Melbourne heads out our occupancy levels go up to about the 80 per cent mark and with our visitors and day-trippers we expect strong numbers from now right up until the end of the summer school holidays in 2022.

"I have full confidence in all our businesses that they will be able to follow the rules and regulations and provide a positive experience, but that doesn't devoid the fact that it is going to be challenging for the first few weeks.

"We are doing everything in our power to make sure everyone is armed with the most up to date information."

Grampians Tourism and a suite of government bodies held an information session earlier in October, with the industry forum focused on reopening the tourism industry to visitors.

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