Ripon MP Louise Staley and South West Coast MP Roma Britnell, both Liberals, voted with the government to pass the legislation during a conscience vote.

Lowan Nationals MP Emma Kealy also voted for the legislation despite having supported a move to suspend debate on euthanasia earlier in the week. 

The legislation will now head to Parliament's upper house with assisted dying supporters hopeful they have the numbers to pass the momentous laws. 

Victoria will be the first state in Australia to offer an assisted dying regime if the legislation is passed.

Exhausted MPs sat through a gruelling session as opponents moved hundreds of amendments in an effort to delay the passage of the bill.

The bill passed the lower house with 47 votes to 37.

-With Benjamin Preiss, Noel Towell, The Age